Neuroanatomic Correlates of Distance and Direction Processing During Cognitive Map Retrieval

Navigating toward a goal and mentally comparing distances and directions to landmarks are processes requiring reading information off the memorized representation of the environment, that is, the cognitive map. Brain structures in the medial temporal lobe, in particular, are known to be involved in the learning, storage, and retrieval of cognitive map information, which is generally assumed to be in allocentric form, whereby pure spatial relations (i.e., distance and direction) connect locations with each other. The authors recorded functional magnetic resonance imaging activity, while participants were submitted to a variant of a neuropsychological test (the Cognitive Map Reading Test; CMRT) originally developed to evaluate the performance of brain-lesioned patients and in which participants have to compare distances and directions in their mental map of their hometown. Our main results indicated posterior parahippocampal, but not hippocampal, activity, consistent with a task involving spatial memory of places learned a long time ago; left parietal and left frontal activity, consistent with the distributed processing of navigational representations; and, unexpectedly, cerebellar activity, possibly related to the role of the cerebellum in the processing of (here, imaginary) self-motion cues. In addition, direction, but not distance, comparisons elicited significant activation in the posterior parahippocampal gyrus.