Altered Sex Ratio at Birth with Maternal Exposure to Dioxins in Vietnamese Infants

Kaneko, Noriko and Nishijo, Muneko and Vu, Hoa Thi and Pham-The, Tai and Pham, Thao Ngoc and Tran, Nghi Ngoc and Takiguchi, Tomoya and Nishino, Yoshikazu (2024) Altered Sex Ratio at Birth with Maternal Exposure to Dioxins in Vietnamese Infants. Toxics, 12 (4). p. 276. ISSN 2305-6304

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Abstract

Excess female births (lower sex ratio at birth) associated with paternal exposure to 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) have been reported in Italy. However, no significant effects of maternal TCDD exposure on the sex ratio were reported. We investigated the effects of maternal TCDD exposure and the toxic equivalent quantity of polychlorinated dibenzo-p-dioxins/dibenzofurans (TEQ-PCDD/Fs) on the sex ratio at birth in 576 Vietnamese infants from three birth cohorts. TCDD and TEQ-PCDD/Fs in breast milk were stratified (low, mild, moderate, and high) as maternal exposure markers. Logistic regression analysis was used to investigate associations between female birth and dioxin exposure groups after adjusting for confounders. In sprayed and unsprayed areas, adjusted odds ratios (ORs) of female birth (reference: low-TCDD group) were 2.11 in the moderate-TCDD group and 2.77 in the high-TCDD group, which were significantly associated with increased TCDD exposure. In sprayed areas, a significantly increased OR in the high-TCDD group was observed. No significant associations, however, were found between having a girl and TEQ-PCDD/F levels. These results suggest that maternal TCDD exposure may alter the sex ratio at birth among Vietnamese residents of areas with high dioxin contamination.

Item Type: Article
Subjects: Apsci Archives > Multidisciplinary
Depositing User: Unnamed user with email support@apsciarchives.com
Date Deposited: 10 Apr 2024 08:13
Last Modified: 10 Apr 2024 08:13
URI: http://eprints.go2submission.com/id/eprint/2714

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