A Study of Anxiety on Experimental Epileptic Rat Models using Dark Light Box

The word neurodegeneration refers to defects in neuronal structure and consequently its function. The main characteristics of these disorders are relentless progression and cognitive declination. Epilepsy is one of the neurodegenerative disorders, around 50 million people in the world are affected with. Though it is one of the major health problems in the present society, there are several gaps in understanding the consequences related to neurological disorders. As research works related to neurodegeneration is very much limited in India we have planned one as an initiative.

We segregated 8 animal groups, each with 6 animals for this work. The animal groups are LC, CO, AC15, AC25, AC35, BA10, BA15 and BA20. This study was conducted on 10th day after the lesion by considering the day of lesion as day ‘1’ and the next day as day 2nd. All the animals were recovered completely within these 10 days and were put in the dark light box to analyse the anxiety level of the animals, so as to analyse the effect of the drug employed. This particular study clearly supported the efficacy of the drug as the drug group animals were less anxious or even behaved normal. Both the crude extract and the selected active principle have proved their efficacy by the study.