THE ANTIHYPERTENSIVE ACTIVITY OF ETHANOL EXTRACT OF Curcuma aeruginosa Roxb ON ADRENALIN-INDUCED MALE RATS

Curcuma aeruginosa is a plant of the Zingiberaceae family known in Indonesia as an herbaceous plant that has a distinctive aroma in its rhizomes and has traditionally been widely used to treat various diseases, one of them is hypertension.

In vivo anti-hypertensive of the ethanol extract of Curcuma aeruginosa Roxb on adrenaline-induced rats has been evaluated by using CODA® noninvasive blood pressure. Sprague Dawley rats were divided into seven groups (five rats each group): normotensive group, negative control (hypertensive group, induced by 1 mg/kg BW adrenaline i.p for 7 days), positive control (propranolol 8,2 mg/kg), and a test group of ethanol extract Curcuma aeruginosa in doses of 150, 300 and 600 mg/kg BW). The evaluation of systolic blood pressure, diastolic blood pressure, and heart rate were followed during 14 days (D0, D7, and D14) using CODA® noninvasive blood pressure. The result exhibited that at doses150, 300, and 600 mg/kg BW of C. aeruginosa ethanolic extract reduced systolic blood pressure (BP), diastolic BP significantly (p 0,05), but did not in heart rate (p 0,05).This result suggested that the ethanol extract of Curcuma aeruginosa has a potency to be developed as the anti-hypertensive agent.