Study on Silica Catalyst Promoted One-Pot Synthesis of 4-[(Dialkylamino)methyl]-1,7- diphenylhepta-1,6-diene-3,5-dione

Silica (SiO2) catalyzed one-pot synthesis of 4-[(dialkylamino)methyl]-1,7-diphenylhepta-1,6-diene-3,5-
dione. An expeditious synthesis under microwave irradiation method for curcumin Mannich base
derivatives are known for its biological activity. Curcumin is naturally occurring yellow pigments
isolated from Curcuma longa, structurally it is polyphenolic compounds consisting spectacular
biological activity. Curcumin is also known as ‘Indian Saffron’, cultivated in most part of India.
Curcumin traditionally recog-nized for its medicinal property in several Asian countries like ‘India’ and
‘China’. However, clinical utility of curcumin is limited due to its poor bioavailability. Present
methodology offers silica catalyzed one pot, productive technique to obtain curcumin Mannich base.
Both, conventional and microwave irradiation methods were found productive. An eco-friendly catalyst
as non-toxic, non-hazardous easily available used for the synthesis of curcumin analogue under
conventional and microwave irradiation method. An expeditious reaction carried out under the
microwave method with good to better yield. The final products were characterized by 1H NMR.