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Raúl and Garcilazo-Ávila, Adrián and Gonzáles-Carballo, Carlos and Aguilar-Ramírez, Diego and Zhu, Doreen and Trichia, Eirini and Chiquete, Erwin and Bragg, Fiona and Whitlock, Gary and Friedrichs, Louisa Gnatiuc and Staplin, Natalie and Bello-Chavolla, Omar Yaxmehen and Haynes, Richard and Clarke, Robert and Lewington, Sarah and Herrington, William and Vergara, Alejandra and Barrera-Sánchez, Elizabeth and Del Vecchyo-Tenorio, Georgina and González-Ruiz, Margarita and Baca-Peynado, Paulina and Liu, Tianshu and Wang, Yunhe and Wong, Adriana Lucrecia Wong y. and Magos, Clementina and Romer, Fredrik and Martínez, Herendira Zambrano and Wheeler, James and Emmens, Kathleen and Youngman, Linda and Radley, Martin and Sanchez, Martha Solano and Lacey, Matthew and Hill, Michael R. and Plunkett, Nigel and Taylor, Paul and Shellard, Richard and Clark, Sarah and Williams, Tim and Fernandez, Gustavo Olaiz and Holland, Lisa and Cervantes, Malaquias López and Baras, Aris and Hill, Michael R. and Emberson, Jonathan R. and Marchini, Jonathan and Kuri-Morales, Pablo and Tapia-Conyer, Roberto (2023) Genotyping, sequencing and analysis of 140,000 adults from Mexico City. Nature, 622 (7984). pp. 784-793. ISSN 0028-0836
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Abstract
The Mexico City Prospective Study is a prospective cohort of more than 150,000 adults recruited two decades ago from the urban districts of Coyoacán and Iztapalapa in Mexico City1. Here we generated genotype and exome-sequencing data for all individuals and whole-genome sequencing data for 9,950 selected individuals. We describe high levels of relatedness and substantial heterogeneity in ancestry composition across individuals. Most sequenced individuals had admixed Indigenous American, European and African ancestry, with extensive admixture from Indigenous populations in central, southern and southeastern Mexico. Indigenous Mexican segments of the genome had lower levels of coding variation but an excess of homozygous loss-of-function variants compared with segments of African and European origin. We estimated ancestry-specific allele frequencies at 142 million genomic variants, with an effective sample size of 91,856 for Indigenous Mexican ancestry at exome variants, all available through a public browser. Using whole-genome sequencing, we developed an imputation reference panel that outperforms existing panels at common variants in individuals with high proportions of central, southern and southeastern Indigenous Mexican ancestry. Our work illustrates the value of genetic studies in diverse populations and provides foundational imputation and allele frequency resources for future genetic studies in Mexico and in the United States, where the Hispanic/Latino population is predominantly of Mexican descent.
Item Type: | Article |
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Subjects: | Apsci Archives > Multidisciplinary |
Depositing User: | Unnamed user with email support@apsciarchives.com |
Date Deposited: | 10 Nov 2023 06:04 |
Last Modified: | 10 Nov 2023 06:04 |
URI: | http://eprints.go2submission.com/id/eprint/2186 |