From Sadness to Heart Disease: A Comprehensive Review on the Correlation between Depression and Cardiovascular Disease

Depression has been underlined as one of the key diagnosis among patients with cardiovascular disease. Academic literature indicates an increased link between depression and cardiovascular disease. Although studies has been done in relation to the pharmacological and cognitive-behavioral therapy, ts impact to the understanding of the association between depression and cardiovascular disease remains a debate. This comprehensive review provides an in-depth understanding of depression, cardiovascular diseases, the epidemiology and pathophysiological mechanism impacting cardiovascular disease with depression, activation of platelet, the effects of anti-depressant treatment, lifestyle of depression with cardio disease patients as well as its relation to sub-Saharan Africa.