Flavonoids in the Treatment of Cirrhosis and Liver Cancer

The aim is to use flavonoids to develop a new formula that regenerates fibrotic hepatocellular epithelium, clears scar tissue, stops progression to hepatocellular carcinoma, and prevents the recurrence of hepatocellular carcinoma. The flavonoids are used to treat compensated cirrhosis (Child Pugh 6) and early stage hepatocellular carcinoma (Hcc) (when the tumor is small in size (< 3cm) and less than 3 tumors). The selective flavonoids in combination with pregnenolone, ascorbic acid, pyridoxine 5-phosphate, and L-arginine are effective in cutting off the liver cells' chronic inflammatory chain and preventing fibrosis. Kupffer cells are not activated to destroy liver cells and do not activate the activation of hepatic stellate cells (HSCs), which help liver enzymes stabilize without disturbing the function of the liver. The process of apoptosis and regeneration of liver cells has helped the liver recover well. The ingredients acted on the hepatocyte protection and regeneration cycles. The composition has demonstrated therapeutic efficacy over 5 years of follow-up with patients. The ascorbic acid, pyridoxine 5-phosphate, pregnenolone, L-arginine, flavonoids, and iso-flavonoids have demonstrated the safety of the composition during treatment. The ingredients are found in nature and are on the FDA's list of approved medicinal substances. The trial was performed retrospectively on people who had been diagnosed with compensated cirrhosis and with or without attachment hepatocellular carcinoma. Through observing all patients using the ingredients contained in the study for different therapeutic purposes beforehand. No cases of severe progression of cirrhosis nor recurrence of hepatocellular carcinoma have been detected. The use of ascorbic acid, pyridoxine 5-phosphate, pregnenolone, L-arginine, flavonoids, and iso-flavonoids in treatment has helped to regenerate liver cells completely, helping the physiological and biochemical functions of the liver to be stabilized, helping the liver to restore its function in the body.