Astrocytes in Neuropathologies Affecting the Frontal Cortex

Peteri, Ulla-Kaisa and Niukkanen, Mikael and Castrén, Maija L. (2019) Astrocytes in Neuropathologies Affecting the Frontal Cortex. Frontiers in Cellular Neuroscience, 13. ISSN 1662-5102

[thumbnail of pubmed-zip/versions/1/package-entries/fncel-13-00044/fncel-13-00044.pdf] Text
pubmed-zip/versions/1/package-entries/fncel-13-00044/fncel-13-00044.pdf - Published Version

Download (319kB)

Abstract

To an increasing extent, astrocytes are connected with various neuropathologies. Astrocytes comprise of a heterogeneous population of cells with region- and species-specific properties. The frontal cortex exhibits high levels of plasticity that is required for high cognitive functions and memory making this region especially susceptible to damage. Aberrations in the frontal cortex are involved with several cognitive disorders, including Alzheimer’s disease, Huntington’s disease and frontotemporal dementia. Human induced pluripotent stem cells (iPSCs) provide an alternative for disease modeling and offer possibilities for studies to investigate pathological mechanisms in a cell type-specific manner. Patient-specific iPSC-derived astrocytes have been shown to recapitulate several disease phenotypes. Addressing astrocyte heterogeneity may provide an improved understanding of the mechanisms underlying neurodegenerative diseases.

Item Type: Article
Subjects: Apsci Archives > Medical Science
Depositing User: Unnamed user with email support@apsciarchives.com
Date Deposited: 29 May 2023 04:43
Last Modified: 23 Dec 2023 08:16
URI: http://eprints.go2submission.com/id/eprint/1118

Actions (login required)

View Item
View Item