Oral Low-Molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis

Galia, Tindara La and Micali, Antonio and Puzzolo, Domenico and Cancellieri, Francesco (2014) Oral Low-Molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis. International Journal of Clinical Medicine, 05 (11). pp. 617-624. ISSN 2158-284X

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Abstract

The aim of this study was to evaluate the effectiveness of low molecular weight hyaluronic acid oral tablets for the treatment of atrophic vaginitis. 12 women with atrophic vaginitis were recruited for this double blind, placebo-controlled study. Patients were randomized to receive either low molecular weight hyaluronic acid (HA) oral tablets or placebo for three months. Vaginal biopsies were taken at baseline and after three months of treatment, and vaginal epithelium was analysed using light microscopy. The evaluation of symptoms was self-assessed by the patients. Biopsies from HA group showed an epithelium thicker than in placebo group. The lamina propria from the HA group also showed a denser appearance compared to placebo group. Morphometric analysis showed significant differences between HA and baseline in the number of epithelial layers and in the thickness. The evaluation of symptoms also showed an effective improvement in the patients treated with HA, compared to baseline and to placebo group. In conclusion, oral administration of HA tablets improved the vaginal epithelium, decreasing atrophy. This can be an ideal option for patients with atrophic vaginitis who do not want to or can not take estrogen and show low compliance toward vaginal administration.

Item Type: Article
Subjects: Apsci Archives > Medical Science
Depositing User: Unnamed user with email support@apsciarchives.com
Date Deposited: 17 Feb 2023 08:24
Last Modified: 09 Feb 2024 04:02
URI: http://eprints.go2submission.com/id/eprint/109

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