Nguyen, Hai Le Thanh and Trujillo-Paez, Juan Valentin and Umehara, Yoshie and Yue, Hainan and Peng, Ge and Kiatsurayanon, Chanisa and Chieosilapatham, Panjit and Song, Pu and Okumura, Ko and Ogawa, Hideoki and Ikeda, Shigaku and Niyonsaba, François (2021) Implication of Antimicrobial Peptides in Atopic Dermatitis: Role in Regulation of Skin Barrier. In: Recent Research Advances in Biology Vol. 8. B P International, pp. 1-18. ISBN 978-93-91215-57-6
Full text not available from this repository.Abstract
Atopic dermatitis (AD) is a common chronic inflammatory skin disease that exhibits a complex interplay of skin barrier disruption and immune dysregulation. Patients with AD are susceptible to cutaneous infections that may progress to complications, including staphylococcal septicemia. Although most studies have focused on filaggrin mutations, the physical barrier and antimicrobial barrier also play critical roles in the pathogenesis of AD. Within the physical barrier, the stratum corneum and tight junctions play the most important roles. The tight junction barrier is involved in the pathogenesis of AD, as structural and functional defects in tight junctions not only disrupt the physical barrier but also contribute to immunological impairments. Antimicrobial peptides (AMPs) are considered a rapid and first-line response of the innate immune system to microbial pathogens. Furthermore, antimicrobial peptides, such as LL-37, human b-defensins, and S100A7, improve tight junction barrier function. Recent studies elucidating the pathogenesis of AD have led to the development of barrier repair therapy for skin barrier defects in patients with this disease. This chapter analyzes the association between skin barrier disruption in patients with AD and antimicrobial peptides to determine the effect of these peptides on skin barrier repair and to consider employing antimicrobial peptides in barrier repair strategies as an additional approach for AD management.
Item Type: | Book Section |
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Subjects: | Apsci Archives > Biological Science |
Depositing User: | Unnamed user with email support@apsciarchives.com |
Date Deposited: | 30 Oct 2023 11:55 |
Last Modified: | 30 Oct 2023 11:55 |
URI: | http://eprints.go2submission.com/id/eprint/1986 |